实验室简介：

本研究室主要从事放射治疗和防护中的重要生物问题方面的研究工作：细胞对辐射的响应；损伤信号产生及传递；辐射导致的遗传损伤等。研究人员尝试为改进放疗效果和辐射防护提供实验基础和理论指导。

实验室研究方向：

辐射旁效应机理研究；低剂量辐射适应性效应机理研究；低剂量一氧化碳的辐射生物防护功能机理；纳米尺度材料的生物危害及生物相容性；肝癌潜在治疗药物研究。

实验室研究成果：

本研究室目前承担中科院“百人计划”择优项目1项，国家自然科学基金面上项目1项，国家自然科学基金青年项目2项，安徽省自然科学基金青年项目1项。代表性论文如下：
1. Wei Han, K.N. Yu, Lijun Wu, Yican Wu and Hongzhi Wang, Mechanism of protection of bystander cells by exogenous carbon monoxide: impaired response to damage signal of radiation-induced bystander effect, Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 709-710(1), 1-6，2011.
2. Wei Han, Lijun Wu, Shaopeng Chen and K.N. Yu, Exogenous carbon monoxide protects the bystander Chinese hamster ovary cells in mixed co-culture system after alpha-particle irradiation, Carcinogenesis, 31(2), 275-280, 2010.
3.  Wei Han, Lijun Wu, Shaopeng Chen, Linzhi Bao, Leilei Zhang, Erkang Jiang, Ye Zhao, An Xu, Tom K. Hei and Zengliang Yu, Constitutive nitric oxide acting as a possible intercellular signaling molecule in the initiation of radiation-induced DNA double strand breaks in non-irradiated bystander cells, Oncogene, 26(16), 2330-2339, 2007.
4.  Wei Han, Lijun Wu, Burong Hu, Leilei Zhang, Shaopeng Chen, Lingzhi Bao, An Xu and Zengliang Yu, The early and initiation process of radiation-induced bystander effects involving in the induction of DNA double strand breaks in non-irradiated cultures, British Journal of Radiology, 80(1), S7-S12, 2007. （邀请文章）
5. Shaopeng Chen, Ye Zhao, Wei Han, Guoping Zhao, Lingyan Zhu, Jun Wang, Linzhi Bao, Erkang Jiang, An Xu, Tom K. Hei, Zengliang Yu and Lijun Wu, Mitochondria-dependent signalling pathway are involved in the early process of radiation-induced bystander effects. British Journal of Cancer, 98(11), 1839-1844, 2008.

实验室联系方式：

室务主任：韩伟 0551-5595100  hanw@hfcas.ac.cn