代表性论文

Zhi Huang; Juan Ge; Yongfei Chen; Fengming Zou; Qingwang Liu; Beilei Wang; Yangguo Zhou; Chao Wu; Wenchao Wang; Aoli Wang;* Jing Liu;* and Qingsong Liu*. Discovery of Novel Purine Derivatives as Potent and Orally Bioavailable PGK1 Inhibitors for the Treatment of InflammatoryBowel Disease.Journal of Medicinal Chemistry. 2025, 68, 21394−21411.

Yongfei Chen; Jiaxin Wu; Aoli Wang; Ziping Qi; Taoshan Jiang; Cheng Chen; Fengming Zou; Chen Hu; Wei Wang; Hong Wu; Zhenquan Hu; Wenchao Wang; Beilei Wang; Li Wang; Tao Ren; Shanchun Zhang; Qingsong Liu*; Jing Liu*. Discovery of N-(5-((5-chloro-4-((2- (isopropylsulfonyl)phenyl)amino) pyrimidin- 2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl) phenyl)acrylamide (CHMFL-ALK/ EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC, European Journal of Medicinal Chemistry, 2017, 139: 674-697.

Beilei Wang; Yuanxin Deng; Yongfei Chen; Kailin Yu; Aoli Wang; Qianmao Liang; Wei Wang; Cheng Chen; Hong Wu; Chen Hu; Weili Miao; Wooyoung Hur; Wenchao Wang; Zhenquan Hu; Ellen L. Weisberg; Jinhua Wang; Tao Ren; Yinsheng Wang; Nathanael S. Gray; Qingsong Liu*; Jing Liu*. Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors, European Journal of Medicinal Chemistry, 2017, 137: 545-557.

Qianmao Liang; Yongfei Chen; Kailin Yu; Cheng Chen; Shouxiang Zhang; Aoli Wang; Wei Wang; Hong Wu; Xiaochuan Liu; Beilei Wang; Li Wang; Zhenquan Hu; Wenchao Wang; Tao Ren; Shanchun Zhang; Qingsong Liu*; Cai-Hong Yun*; Jing Liu*. Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4- carbonyl) phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2- methylphenyl)-4-(tertbutyl) benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor, European Journal of Medicinal Chemistry, 2017, 131: 107-125.

H Wu; C Hu; A Wang; EL Weisberg; Y Chen; C-H Yun; W Wang; Y Liu; X Liu; B Tian; J Wang; Z Zhao; Y Liang; B Li; L Wang; B Wang; C Chen; SJ Buhrlage; Z Qi; F Zou; A Nonami; Y Li; SM Fernandes; S Adamia; RM Stone; IA Galinsky; X Wang; G Yang; JD Griffin; JR Brown; MJ Eck; J Liu*; NS Gray*; Q Liu*. Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia, Leukemia, 2016, 30: 173-181.

专利

刘青松；刘静；陈永飞；黄志；葛娟；邹凤鸣；王傲莉；刘青旺；亓爽；齐紫平；吴宏；王文超；王蓓蕾；王黎；含有嘌呤环的化合物及其用途，2024-01-09，CN202410029938X

刘静；刘青松；梁前茅；陈永飞；陈程；王傲莉；吴宏；余凯琳；王伟；胡晨；王文超；亓爽；王蓓蕾；王黎；一种新型布鲁顿酪氨酸激酶不可逆抑制剂，2016-02-04，CN201610084082.1

刘青松；刘静；江桃山；王傲莉；吴佳昕；吴宏；齐紫平；陈永飞；邹凤鸣；王文超；赵铮；王黎；王蓓蕾；一种新型的EGFR/ALK激酶的双重抑制剂，2015-12-15，201510946305.6

刘青松；刘静；陈永飞；吴宏；王傲莉；王蓓蕾；胡晨；王文超；陈程；一种新型布鲁顿酪氨酸激酶抑制剂，2014-06-19，CN201410280931.1

承担项目

天然生物碱Lymphostin对mTOR激酶抑制的分子机理研究，安徽省自然科学基金面上项目，2015.05—2017.06