马凯,中国科学院合肥物质科学研究院健康与医学技术研究所副研究员,博士毕业于北京协和医学院。曾先后于美国希望之城国家医疗中心、西湖大学进行博士后研究工作。担任中国抗癌协会肿瘤病因学专业委员会委员。在Cell Research, Cell Discovery, Cancer Letters,Advanced Science等主流学术期刊发表论文十余篇。
长期从事DNA损伤所导致的细胞衰老以及肿瘤发生机制等相关研究,并积极探索基于衰老细胞清除的肿瘤治疗新策略。
代表性论文
Ma, Kai*; Yin, Kaili*; Li, Jiong; Ma, Li; Zhou, Qun; Lu, Xiyuan; Li, Bo; Li, Juxue; Wei, Gang; Zhang, Guo; The Hypothalamic Epigenetic Landscape in Dietary Obesity, Advanced Science, 2024, 11(9).
Ma, Kai; Luo, Man; Xie, Guanglei; Wang, Xi; Li, Qilin; Gao, Lei; Yu, Hongtao; Yu, Xiaochun; Ribosomal RNA regulates chromosome clustering during mitosis, Cell discovery, 2022, 8(1).
Chen, Qian*; Ma, Kai*; Liu, Xiuhua; Chen, Shih-Hsun; Li, Peng; Yu, Yonghao; Leung, Anthony K. L.; Yu, Xiaochun; Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis, Cell Discovery, 2022, 8(1).
Ma, Kai; Xu, Qing; Wang, Shuren; Zhang, Weina; Liu, Mei; Liang, Shufang; Zhu, Hongxia; Xu, Ningzhi; Nuclear Accumulation of YAP Promotes the Expression of survivin to Maintain the Survival of Adrimycin Induced Senescent Cells, Cancer Letters, 2016, 375(1): 84-91.
Gai, Xiaochen; Xin, Di; Wu, Duo; Wang, Xin; Chen, Linlin; Wang, Yiqing; Ma, Kai; Li, Qilin; Li, Peng; Yu, Xiaochun; Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response, Cell Research, 2022, 32(3): 254-268.
承担项目
RNA甲基转移酶NOL1抵抗细胞衰老促进胰腺癌发生的作用和机制研究,青年科学基金项目(C类), 82302896, 2024-2026, 主持