简  介

张帆，女，现任中科院合肥研究院健康与医学技术研究所基因组学团队研究员，博士生导师。2004年本科毕业于哈尔滨工业大学，2011年博士毕业于哈尔滨医科大学；2013到2016年间在美国纽约西奈山医学院从事博士后研究，2017到2023年间在哈尔滨工业大学工作，历任副研究员，研究员。2023年5月入职中国科学院合肥研究院。

研究方向

主要从事肿瘤等重大疾病和宿主免疫系统相互作用的分子机制研究，具体包括：肿瘤早筛标记物识别，肿瘤的免疫编辑分子机制研究，肿瘤免疫浸润的异质性研究，循环肿瘤DNA、微生物宏基因组等高通量测序数据及各种单细胞组学数据挖掘的人工智能算法开发等。

发表论文

在Cell Research (2024, IF:44.1)、Nucleic Acids Research (2023, IF:19.16)、Cell (2021, IF: 41.582)、Signal Transduction and Targeted Therapy (STTT  2篇：2020 封面故事；2021，IF: 38.12)，Cancer Research (2019,2016，IF: 12.701)、Molecular Cell (2017，IF: 19.328)和Briefings in Bioinformatics (2016, IF: 9.5) 等杂志上发表一作及通讯作者（含并列）SCI论文.

Selected publications:

(1). Zhou F#*, Yu X#, Gan R#, Ren K, Chen C, Ren C, Cui M, Liu Y, Gao Y, Wang S, Yin M, Huang T, Huang Z*, Zhang Fan *. CRISPRimmunity: an interactive web server for CRISPR-associated Important Molecular events and Modulators Used in geNome edIting Tool identifYing. Nucleic Acids Res. 2023 Jul 5;51(W1):W93-W107. (IF: 14.9, corresponding author)

(2) Ren K#, Zhou F#, Zhang F(#*), Yin M#, Zhu Y#, Wang S#, Chen Y, Huang T, Wu Z, He J, Zhang A, Guo C, Huang Z*. Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs. Cell Res. 2024 Apr 4. doi: 10.1038/s41422-024-00952-1. Epub ahead of print. PMID: 38575718. (IF: 44.1, corresponding author)

(3) Fan Zhang(#), Rui Gan(#), Ziqi Zhen(#), Xiaoli Hu(#), Xiang Li, Fengxia Zhou, Ying Liu, Chuangeng Chen, Shuangyu Xie, Bailing Zhang, Xiaoke Wu & Zhiwei Huang*. Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals. Sig Transduct Target Ther 5, 156 (2020)(IF: 38.12 cover story)

(4) Fan Zhang, Zhiwei Huang*. Mechanistic Insights into the Versatile Class II CRISPR Toolbox. Trends in Biochemical Sciences. (IF: 13.807, invited review 2021)

(5) Shengli Ma(#)*, Fan Zhang(#), Fengxia Zhou(#), Hui Li(#), Wenyu Ge, Rui Gan, Huan Nie, Biao Li, Yindong Wang, Meng Wu, Duo Li, Dongmei Wang, Zheng Wang, Yuhong You & Zhiwei Huang* Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19. Sig Transduct Target Ther 6, 191 (2021)(IF: 38.12 co-first author)

(6) Zhang, R.(#), F. Zhang(#), Z. Sun(#), P. Liu, X. Zhang, Y. Ye, B. Cai, M. J. Walsh, X. Ren, X. Hao, W. Zhang* and J. Yu* (2019). "LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor Suppressor Gene FGGY." Cancer Research: canres.0076.2019. （co-first author, IF：12.701）

(7) Zhang, F.(#*), Zhao, S.(#), Ren, C.(#), Zhu, Y., Zhou, H., Lai, Y., Zhou, F., Jia, Y., Zheng, K. and Huang, Z*. (2018) CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactions. Commun Biol, 1, 180. (IF：6.268)

(8) Fan Zhang*, Chunyan Ren, Kwun Kit Lau, Zihan Zheng, Geming Lu, Zhengzi Yi, Yongzhong Zhao, Fei Su, Shaojun Zhang, Bin Zhang, Eric A. Sobie, Weijia Zhang*, Martin J. Walsh*, A network medicine approach to build a comprehensive atlas for the prognosis of human cancer, BRIEFINGS IN BIOINFORMATICS, 2016.11, 17(6): 1044~1059 （IF：9.5）

(9) Ka Lung Cheung(#), Fan Zhang(#), Anbalagan Jaganathan(#), Rajal Sharma, Qiang Zhang, Tsuyoshi Konuma, Tong Shen, June-Yong Lee, Chih-Hung Chen, Geming Liu, Weijia Zhang, Dan R. Littman, Martin J. Walsh, Huabao Xiong, & Ming-Ming Zhou* Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation, MOLECULAR CELL, 2017.3.16, 65(6): 1068~+ （co-first author IF：17.970）

(10) Fan Zhang, Won-min Song, SiDe Li, Vashisht Ajay, Francesca Aguilo, Anindya Bagchi, James A. Wohlschlegel, Bin Zhang, Martin Walsh. The enhancer landscape involves a core noncoding RNA protein interaction network for C-MYC expression. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl).

(11) Aguilo F*, Zhang F, Sancho A, Fidalgo M, Di Cecilia S, Vashisht A, Lee DF, Chen CH, Rengasamy M, Andino B, Jahouh F, Roman A, Krig SR, Wang R, Zhang W, Wohlschlegel JA, Wang J, Walsh MJ*. Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming. Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming, CELL STEM CELL, 2015.12.3, 17(6): 689~704 （IF：24.633）

(12) Guo H, Ahmed M, Zhang F, Yao CQ, Li S, Liang Y, Hua J, Soares F, Sun Y, Langstein J, Li Y, Poon C, Bailey SD, Desai K, Fei T, Li Q, Sendorek DH, Fraser M, Prensner JR, Pugh TJ, Pomerantz M, Bristow RG, Lupien M, Feng FY, Boutros PC, Freedman ML, Walsh MJ, He HH*. Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer, NATURE GENETICS, 2016.10, 48(10): 1142~1150 （IF：38.330）

(13) Rengasamy M, Zhang F, Vashisht A, Song WM, Aguilo F, Sun Y, Li S, Zhang W, Zhang B, Wohlschlegel JA, Walsh MJ*. The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer, NUCLEIC ACIDS RESEARCH, 2017.8.21, 45(19): 11106~11120 （IF：16.971）

(14) Di Cecilia S, Zhang F, Sancho A, Li S, Aguiló F, Sun Y, Rengasamy M, Zhang W, Del Vecchio L, Salvatore F, Walsh MJ*. RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells., Cancer Res, 2016.10.1, 76(19): 5615~5627 （IF：12.701）

(15) Ren, X.#,Wen, W.#, Fan, X.#, Hou, W.#, Su, B.#, Cai, P.#, Li, J.#, Liu, Y.#, Tang, F. #, Zhang, F. #, Yang, Y.#, He, J. #, Ma, W. #, He, J. #, Wang, P. #, Cao, Q., Chen, F., Chen, Y., Cheng, X., Deng, G., Deng, X., Ding, W., Feng, Y., Gan, R., Guo, C., Guo, W., He, S., Jiang, C., Liang, J., Li, Y.-m., Lin, J., Ling, Y., Liu, H., Liu, J., Liu, N., Liu, S.-Q., Luo, M., Ma, Q., Song, Q., Sun, W., Wang, G., Wang, F., Wang, Y., Wen, X., Wu, Q., Xu, G., Xie, X., Xiong, X., Xing, X., Xu, H., Yin, C., Yu, D., Yu, K., Yuan, J., Zhang, B., Zhang, P., Zhang, T., Zhao, J., Zhao, P., Zhou, J., Zhou, W., Zhong, S., Zhong, X., Zhang, S., Zhu, L., Zhu, P., Zou, B., Zou, J., Zuo, Z., Bai, F., Huang, X., Zhou, P., Jiang, Q.*, Huang, Z. *, Bei, J.-X. *, Wei, L. *, Bian, X.-W. *, Liu, X. *, Cheng, T. *, Li, X. *, Zhao, P. *, Wang, F.-S. *, Wang, H. *, Su, B. *, Zhang, Z. *,Qu, K. *, Wang, X. *, Chen, J. *, Jin, R. *, Zhang, Z. *, COVID-19 immune features revealed by a large-scale single cell transcriptome atlas, Cell (2021)(co-first author，IF: 41.582)

主持或参与主要科研项目

主持国家自然科学基金面上项目1项和青年项目1项，参与国自然联合基金重点支持项目、黑龙江省级项目等。

学术任职

中国抗癌协会肿瘤标志专委会、肿瘤测序大数据分析专家委员会委员；中国生物信息学表观遗传信息学专委会委员。

招生专业

博士招生计划：

专业：生物物理学招生方向：计算生物学或生物信息学

学术硕士招生计划：

专业：生物物理学（硕士）招生方向：计算生物学或生物信息学

专业学位硕士招生计划：

专业：物与医药（专硕）招生方向：计算生物学或生物信息学

工程博士招生计划：

专业：电子信息招生方向：计算机技术或软件工程

联系方式

地址：安徽省合肥市蜀山湖路350号科学岛健康与医学技术研究所，邮编：230031

电子邮箱：fzhang@cmpt.ac.cn