代表性论文

Guo M, Dai Y, Zhuang X, Yang W*, Chang J*. METTL3-mediated m6A modification of SIRT1 mRNA modulates podocyte autophagy in diabetes nephropathy with the treatment effect of Astragalus polysaccharide. Int J Biol Macromol. 2025 Dec 3;337(Pt 1):149473. doi: 10.1016/j.ijbiomac.2025.149473. Epub ahead of print. PMID: 41349753.

Chen A, Yin K, Cui Q, Liu Y, Wan X, Yang W*. Preventing liver carcinogenesis through the use of inhibitors targeting metabolic enzymes ACLY, G6PD, and TYMS, combined with 9-cis retinoic acid. Int J Biol Macromol. 2025 Oct 18:148378. doi: 10.1016/j.ijbiomac.2025.148378. Epub ahead of print. PMID: 41115561.

Chen Y, Tang X, Zhu L, Wang Y, Li G, Yang W*. FPR3 orchestrates macrophage polarization in breast cancer: multi-omics dissection of prognostic relevance and therapeutic targeting. Cancer Cell Int. 2025 Aug 18;25(1):306. doi: 10.1186/s12935-025-03942-4. PMID: 40826412.

Yin Y, Li X, Li D, Hu Y, Wu Q, Zhao J, Sun Q, Wang HQ, Yang W*. A two-step joint model based on deep learning realizes intelligent recognition of exfoliated cells in serous effusion. Comput Biol Chem. 2025 Aug 9;120(Pt 1):108616. doi: 10.1016/j.compbiolchem.2025.108616. Epub ahead of print. PMID: 40784070.

Li R, Lou Q, Zhu Y, Si M, Zhu X, Jia H, Yang H, Ji T, Xu D, Yang W*, Luo S*, Wang Y*. Mechanism of Huoshan large-leaf yellow tea in treatment of diabetic cognitive dysfunction based on bioinformatics and network pharmacology. Phytomedicine. 2025 Jun 7;144:156923. doi: 10.1016/j.phymed.2025.156923. Epub ahead of print. PMID: 40505484.

Chen H, Cui Q, Yang W*. NF-κB Activation Is Essential for Cervical Cell Proliferation and Malignant Transformation. Int J Mol Sci. 2025 Mar 11;26(6):2493. doi: 10.3390/ijms26062493. PMID: 40141137; PMCID: PMC11942554.

Liu X, Zhang W, Wang H, Yang W*. Identification of CKAP2 as a Potential Target for Prevention of Gastric Cancer Progression: A Multi-Omics Study. Int J Mol Sci. 2025 Feb 12;26(4):1557. doi: 10.3390/ijms26041557. PMID: 40004022; PMCID: PMC11855583.

Wan X, Deng Q, Chen A, Zhang X, Yang W*. Bioinformatics analysis and experimental validation of the oncogenic role of COL11A1 in pan-cancer. 3 Biotech. 2024 Dec;14(12):290. doi: 10.1007/s13205-024-04133-0. Epub 2024 Nov 4. PMID: 39507058; PMCID: PMC11534945.

Tang X, Liu Y, Zhao J, Fu C, Yang W*. Subtyping of gastric cancer based on basement membrane genes that stratifies the prognosis, immune infiltration and therapeutic response. Discov Oncol. 2024 Aug 20;15(1):362. doi: 10.1007/s12672-024-01238-z. PMID: 39164593; PMCID: PMC11336019.

Fu, C., Ji, W., Cui, Q., Chen, A., Weng, H., Lu, N., & Yang, W*. (2024). GSDME-mediated pyroptosis promotes anti-tumor immunity of neoadjuvant chemotherapy in breast cancer. Cancer immunology, immunotherapy : CII, 73(9), 177. https://doi.org/10.1007/ s00262-024-03752-z

Chen, A., Yin, K., Liu, Y., Hu, L., Cui, Q., Wan, X., & Yang, W*. (2024). WEE Family Kinase Inhibitors Combined with Sorafenib Can Selectively Inhibit HCC Cell Proliferation. Current cancer drug targets, 10.2174/0115680096298370240520093003. Advance online publication. https://doi.org/10.2174/0115680096298370240520093003

Cui, W., Yang, J., Tu, C., Zhang, Z., Zhao, H., Qiao, Y., Li, Y., Yang, W., Lim, K. L., Ma, Q., Zhang, C., & Lu, L. (2024). Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation. Cell death & disease, 15(5), 350. https://doi.org/10.1038/s41419-024-06737-z

Yin, Y., Cui, Q., Zhao, J., Wu, Q., Sun, Q., Wang, H. Q., & Yang, W*. (2024). Integrated Bioinformatics and Machine Learning Analysis Identify ACADL as a Potent Biomarker of Reactive Mesothelial Cells. The American journal of pathology, 194(7), 1294–1305. https://doi.org/10.1016/j.ajpath.2024.03.013

Li, R., Lou, Q., Ji, T., Li, Y., Yang, H., Ma, Z., Zhu, Y., Qian, C., Yang, W*. Wang, Y., & Luo, S. (2024). Mechanism of Astragalus mongholicus Bunge ameliorating cerebral ischemia-reperfusion injury: Based on network pharmacology analysis and experimental verification. Journal of ethnopharmacology, 329, 118157. https://doi.org/10.1016/j.jep.2024.118157

Deng, Q., Zhang, X., Wan, X., Zheng, X., Wang, H., Zhao, J., Wang, H. Q., & Yang, W*. (2024). The chemokine CCL20 can assist AFP in serological diagnosis of hepatocellular carcinoma. Heliyon, 10(5), e26774. https://doi.org/10.1016/j.heliyon.2024.e26774

Yang, J., Yang, N., Zhao, H., Qiao, Y., Li, Y., Wang, C., Lim, K. L., Zhang, C., Yang, W*., & Lu, L. (2023). Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice. Stem cell research & therapy, 14(1), 239. https://doi.org/10.1186/s13287-023-03463-9

Cui Q, Zhao J, Deng Q, Liu Y, Fu C, Wu Q, Sun Q, Weng H, Dai H, Yang W. HMGB3 is a potential diagnostic marker for early cervical lesion screening. Genes Dis. 2023 Mar 27;10(6):2202-2205. doi: 10.1016/j.gendis.2023.02.033. PMID: 37554211; PMCID: PMC10404999.

Zhang X, Deng Q, Wan X, Zhao J, Zheng X, Wang H, Wang HQ, Yang W*. Pan-cancer analysis reveals the associations between MMP13 high expression and carcinogenesis and its value as a serum diagnostic marker. Aging (Albany NY). 2023 Mar 22;15(6):2115-2135. doi: 10.18632/aging.204599. Epub 2023 Mar 22.

hao J, Liu Y, Cui Q, He R, Zhao JR, Lu L, Wang HQ, Dai H, Wang H, Yang W*. A prediction model for prognosis of gastric adenocarcinoma based on six metabolism-related genes. Biochem Biophys Rep. 2023 Feb 18;34:101440. doi: 10.1016/j.bbrep.2023.101440.

Hu L, Liu Y, Fu C, Zhao J, Cui Q, Sun Q, Wang H, Lu L, Dai H, Xu X, Yang W*. The Tumorigenic Effect of the High Expression of Ladinin-1 in Lung Adenocarcinoma and Its Potential as a Therapeutic Target. Molecules. 2023 Jan 22;28(3):1103. doi: 10.3390/molecules28031103.

Xie Xin-Ping, Yang Wulin, Zhang Lei and Wang Hong-Qiang, Identifying Biomarkers of Cisplatin Sensitivity in Non-Small Cell Lung Cancer via Comprehensive Integrative Analysis, Current Bioinformatics 2022; 17(6). https://dx.doi.org/10.2174/1574893617666220407105905.

Sun YY, Chen WJ, Huang ZP, Yang G, Wu ML, Xu DE, Yang WL, Luo YC, Xiao ZC, Xu RX, Ma QH. TRIM32 Deficiency Impairs the Generation of Pyramidal Neurons in Developing Cerebral Cortex. Cells. 2022 Jan 28;11(3):449. doi: 10.3390/cells11030449.

Fu C, Wang G, Yang W*. Vascular Thrombosis and Anti-PD-1 Therapy: A Series of Cases. Cancer Manag Res. 2021 Nov 25;13:8849-8853.

Yang H, Deng Q, Ni T, liu Y, Lu L, Dai H, Wang H, Yang W*. Targeted Inhibition of LPL/FABP4/CPT1 fatty acid metabolic axis can effectively prevent the progression of nonalcoholic steatohepatitis to liver cancer. Int J Biol Sci 2021; 17(15):4207-4222.

Fu C,  Liu Y,  Han X,  Pan Y,  Wang HQ,  Wang H,  Dai H,  Yang W*. An Immune-Associated Genomic Signature Effectively Predicts Pathologic Complete Response to Neoadjuvant Paclitaxel and Anthracycline-Based Chemotherapy in Breast Cancer. Front Immunol 2021; 12:704655.

Qi J,  Liu Y,  Hu J,  Lu L,  Dou Z,  Dai H,  Wang H,  Yang W*. Identification of FPR3 as a Unique Biomarker for Targeted Therapy in the Immune Microenvironment of Breast Cancer. Front Pharmacol 2020; 11:593247.

Liu Y,  Qi J,  Dou Z,  Hu J,  Lu L,  Dai H,  Wang H,  Yang W*. Systematic expression analysis of WEE family kinases reveals the importance of PKMYT1 in breast carcinogenesis. Cell Prolif 2020 Feb; 53(2):e12741.

Niu X,  Zhao Y,  Yang N,  Zhao X,  Zhang W,  Bai X,  Li A,  Yang W*,  Lu L*. Proteasome activation by insulin-like growth factor-1/nuclear factor erythroid 2-related factor 2 signaling promotes exercise-induced neurogenesis. Stem Cells 2020 02; 38(2):246-260.

专利

一种尿路上皮细胞标志物及其在尿路上皮细胞癌诊断中的应用（202511789939.5）

一种宫颈病变早期筛查和诊断的分子标志物及其应用（202011194681.1）

一种间皮细胞标志物及其应用（202311482133.2）

一组用于预测乳腺癌新辅助化疗敏感性的基因标签及应用（202110320031.5）

一种乳腺癌分子标志物及其应用（202311484810.4）

一种胃癌预后分子标志物、胃癌预后模型及应用（202311532350.8）

一种筛查和或诊断宫颈癌的分子标志物及其应用(202510051617.4)

一种基于微磁场的免疫肿瘤细胞筛选系统（202310160933.6）

一种控制肺癌细胞活力的分子靶标及其应用（201810568806.9）

承担项目

创新标志物引领的尿液脱落细胞良恶性鉴别技术在尿路上皮癌早期精准诊断中的应用，合肥市自然科学基金，2025.09-2028.08

基于机器学习的间皮细胞特异分子标志物发现及其在胸腹水脱落细胞良恶性鉴别中的应用, 合肥市自然科学基金，2023.09-2026.08

一项宫颈癌前筛查的新技术及检测试剂盒的开发应用, 皖江新兴产业技术发展中心产业化基金, 2023.12-2026.01

基于HMGB3标记开发宫颈病变早期筛查的新方法研究, 合肥市自然科学基金 2022.07-2025.06