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蒋焱熠，男，中国科学院合肥物质科学研究院健康与医学技术研究所副所长、研究员、中国科学技术大学博士生导师。2014年7月于中国医学科学院/北京协和医学院获理学博士学位，师从王明荣教授；2014年9月至2020年10月分别在新加坡国立大学（NUS）癌症研究所和加州大学洛杉矶分校（UCLA）医学院Cedars-Sinai 医学中心 H. Phillip Koeffler 教授课题组从事博士后研究；2021年加入中科院合肥物质科学研究院健康与医学技术研究所，创立癌变机理与精准诊疗课题组任课题组长，继续从事肿瘤个体化精准诊疗研究。 绘制和解析了食管癌的表观遗传修饰图谱，揭示了食管癌特异性核心转录调控网络，并发现表观遗传抑制剂的联合使用在抗肿瘤生长中的重要潜力。已发表SCI论文60余篇，总引用超3000次，包括消化道疾病知名期刊Gut和 Gastroenterology；Nature系列期刊Nature Genetics 和 Nature Communications等。入选中科院百人计划并获择优支持，主持国家自然科学基金、安徽省杰青和DeGregorio Foundation等科研项目。担任Nature Cell Biology、Nature Communications、Cell Reports Medicine、Advanced Science和Cell Reports等杂志审稿人。
针对严重影响人民生命健康的重大疾病，如恶性肿瘤，（1）运用单细胞测序技术和多组学等技术，阐释影响肿瘤免疫治疗效果的重要因素和相关微环境事件，解析不同患者免疫疗效差异性的细胞和分子学基础；（2）开发不同生理病理状态下的类器官模型及共培养体系，建立癌症治疗疗效评估平台，挖掘合理的临床诊疗新标志物和新策略。
代表性论文
Shuai Kong#, Huaguang Pan#, Yuan-Wei Zhang#, Fei Wang, Jian Chen, Jinxiu Dong, Chuntong Yin, Jiaqi Wu, Dan Zhou, Jingyi Peng, Junboya Ma, Jianian Zhou, Dianlong Ge, Yan Lu, Dan-Dan Wei, Jinman Fang, Wei Han, Chengyin Shen, H. Phillip Koeffler, Boshi Wang*, Yuan Jiang*, Yan-Yi Jiang*. Targeting super-enhancer associated oncogene-ALDH3A1 enhances ferroptosis sensitivity in squamous cancer. Oncogene. 2025 Apr;44(15):1037-1050.
Yuan Jiang#, Yue-Yuan Zheng#, Yuan-Wei Zhang#, Shuai Kong#, Jinxiu Dong; Fei Wang, Benjamin Ziman, Sigal Gery, Jia-Jie Hao, Dan Zhou, Jianian Zhou, Allen S. Ho, Uttam K. Sinha, Jian Chen, Shuo Zhang, Chuntong Yin, Dan-Dan Wei, Masaharu Hazawa, Huaguang Pan, Zhihao Lu, Wen-Qiang Wei, Ming-Rong Wang, H. Phillip Koeffler, De-Chen Lin*, Yan-Yi Jiang*. Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer. Nature Communications. 2024 Mar 20;15(1):2484.
Yuan Jiang#, Hua Zhao#, Shuai Kong, Dan Zhou, Jinxiu Dong, Yulan Cheng, Shuo Zhang, FeiWang, Andrew Kalra, Nina Yang, Dan-Dan Wei, Jian Chen, Yuan-Wei Zhang, De-Chen Lin*, Stephen J.Meltzer*, Yan-Yi Jiang*. Establishing mouse and human oral esophageal organoids to investigate the tumor immune response. Disease Models & Mechanisms. 2024 Jan 1;17(1).
Tiantian Jing#, Dianhui Wei, Xiaoli Xu, Chengsi Wu, Lili Yuan, Yiwen Huang, Yizhen Liu, Yan-Yi Jiang*, Boshi Wang*. Transposable elements-mediated recruitment of KDM1A epigenetically silences HNF4A expression to promote hepatocellular carcinoma. Nature Communications. 2024 Jul 4;15(1):5631.
Han Xie#,*, Yan-Yi Jiang#, Yufei Xiang#, Baoming Wu#, Jiajia Zhao, Ruixiang Huang, Mengting Wang, Yunlong Wang, Jun Liu, Dejun Wu, Dasheng Tian*, Erbao Bian*. Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia. Neuro Oncol. 2024 Aug 5;26(8):1438-1452.
Dan-Dan Wei#, Jinman Fang, Huanzhong Wang, Jian Chen, Shuai Kong, Yan-Yi Jiang*, Yuan Jiang*. Perioperative immunotherapy for ESCC, Frontiers in Immunology. 2024 Feb 19:15:133078.
MengTing Wang#, QingYang Chen#, ShuJie Wang#, Han Xie, Jun Liu, RuiXiang Huang, YuFei Xiang, Yan-Yi Jiang*, DaSheng Tian*, ErBao Bian*. J Exp Clin Cancer Res. 2023 42:183.
Yuan Jiang#, Yan-Yi Jiang*, De-Chen Lin*. Super-enhancer-mediated core regulatory circuitry in human cancer. Comput Struct Biotechnol J. 2021 May 5;19:2790-2795.
Li-Yan Li#,*, Qian Yang#, Yan-Yi Jiang#, Wei Yang, Yuan Jiang, Xiang Li, Masaharu Hazawa, Bo Zhou, Guo-Wei Huang, Xiu-E Xu, Sigal Gery, Ling-Wen Ding, Allen S. Ho, Zachary S. Zumsteg, Ming-Rong Wang, Melissa J. Fullwood, Stephen J. Freedland, Stephen J. Meltzer, Li-Yan Xu*, En-Min Li*, H. Phillip Koeffler, De-Chen Lin*. Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer. Nature Communications. 2021 Jul 16; 12 (1): 4362.
Li Chen#, Moli Huang#, Jasmine Plummer#, Jian Pan#, Yan-Yi Jiang#, Qian Yang, Tiago Chedraoui Silva, Nicole Gull, Stephanie Chen, Ling-Wen Ding, Omer An, Henry Yang, Yulan Cheng, Jonathan W Said, Ngan Doan, Winand NM Dinjens, Kevin M Waters, Richard Tuli, Simon A Gayther, Samuel J Klempner, Benjamin P Berman*, Stephen J Meltzer*, De-Chen Lin*, H. Phillip Koeffler*. Master transcription factors form inter-connected circuitry and orchestrate transcriptional network in EAC. Gut. 2020 Apr; 69 (4): 630-640.
Yan-Yi Jiang#, Yuan Jiang#*, Chun-Quan Li#, Ying Zhang#, Pushkar Dakle#, Harvinder Kaur, Jian-Wen Deng, Ruby Yu-Tong Lin, Lin Han, Jian-Jun Xie, Yiwu Yan, Ngan Doan, Yueyuan Zheng, Anand Mayakonda, Masaharu Hazawa, Liang Xu, YanYu Li, Luay Aswad, Maya Jeitany, Deepika Kanojia, Xin-Yuan Guan, Jonathan W. Said, Wei Yang, Melissa J. Fullwood*, De-Chen Lin*, H. Phillip Koeffler. TP63, SOX2 and KLF5 Establish Core Regulatory Circuitry and Construct Cancer Specific Epigenome in ESCC. Gastroenterology. 2020 Oct;159(4):1311-1327.e19.
Yuan Jiang#, Yan-Yi Jiang#*, Jian-Jun Xie#, Anand Mayakonda#, Masaharu Hazawa, Li Chen, Jin-Fen Xiao, Chun-Quan Li, Mo-Li Huang, Ling-Wen Ding, Qiao-Yang Sun, Liang Xu, Deepika Kanojia, Maya Jeitany, Jian-Wen Deng, Lian-Di Liao, Harmik J. Soukiasian, Benjamin P. Berman, Jia-Jie Hao, Li-Yan Xu, En-Min Li, Ming-Rong Wang, Xin-Gang Bi, De-Chen Lin*, H. Phillip Koeffler. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nature Communications. 2018 Sep 6; 9 (1): 3619.
Yan-Yi Jiang#*, De-Chen Lin#*, Anand Mayakonda#, Masaharu Hazawa, Ling-Wen Ding, Wen-Wen Chien, Liang Xu, Ye Chen, Jin-Fen Xiao, William Senapedis, Erkan Baloglu, Deepika Kanojia, Shang Li, Xin Xu, Henry Yang, Jeffrey W Tyner*, Ming-Rong Wang*, H. Phillip Koeffler. Targeting Super-Enhancer associated oncogenes in esophageal squamous cell carcinoma. Gut. 2017 Aug; 66 (8): 1358-1368.
Yuan Jiang#, Yan-Yi Jiang#*, Anand Mayakonda, Mo-Li Huang, Ling-Wen Ding, Lin Han, Fenggang Yu, Yannan Lu, Thomas Kwok Seng Loh, Marilynn Chow, Samantha Savage, Jeffrey W Tyner, De-Chen Lin*, H. Phillip Koeffler*. Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma. Cancer Res. 2017 Dec 1; 77 (23): 6614-6626.
Jia-Jie Hao#, De-Chen Lin#, Huy Q Dinh#, Anand Mayakonda#, Yan-Yi Jiang#, Chen Chang, Ye Jiang, Chen-Chen Lu, Zhi-Zhou Shi, Xin Xu, Yu Zhang, Yan Cai, Jin-Wu Wang, Qi-Min Zhan, Wen-Qiang Wei, Benjamin P Berman*, Ming-Rong Wang*, H. Phillip Koeffler*. Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nat Genet. 2016 Dec; 48 (12): 1500-1507.
Yan-Yi Jiang#, Li Shang, Zhi-Zhou Shi, Tong-Tong Zhang, Sai Ma, Yu Zhang, Jia-Jie Hao, Chao Shi, Feng Shi, Xin Xu, Yan Cai, Qi-Min Zhan, Ming-Rong Wang*. Microtubule-associated protein 4 (MAP4) is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma. Oncogene. 2016 Sep15; 35 (37): 4846-56.
