代表性论文

Wu T, Qi S, Shi C, Wu C, Liu Q, Hu C, Hu J, Wang A, Liu J, Qi Z, Wang W, Liu Q. BMX inhibition overcomes small cell lung cancer chemoresistance by stabilizing E2F1 via ERK1/2-Cyclin D1/CDK4/6 axis Signal Transduct Target Ther. 2026 Apr 8;11(1):125. doi: 10.1038/s41392-026-02644-1.

Hou M, Zhang W, Qi Z, Li G, Mei H, Qi S, Jin R, Zhao Y, Tang X, Xiu B, Chen X, Zhao Y, Hu C, Qian C, Li X, Xu Z, Chen Y, Wu C, Wang B, Yan L, Li D, Huang Y, Liang R, Wang A, Liu J, Wang W, Li B, Long J, Li P, Liang A, Liu Q, Yang J. Timosaponin AIII enhances CAR-T cell potency and prevents relapse through impairing CAR-Tregs Nat Commun. 2026 Mar 31;17(1):3045. doi: 10.1038/s41467-026-70867-5.

Tao Q, Li X, Yu H, Zou F, Liu J, Liu Q, Wang A, Hu C, Wang L, Wang W, Wang B, Liu Q, Liu J. Discovery of a 1H-Pyrazol-3-Amine Derivative as a Novel, Selective, and Orally Available RIPK1 Inhibitor for the Treatment of Inflammatory Disease J Med Chem. 2025 Oct 23;68(20):21766-21785. doi: 10.1021/acs.jmedchem.5c02124. Epub 2025 Oct 12.

Hu J, Liu J, Zou F, Li X, Yu H, Wang B, Wang L, Tang J, Hou X, Gao Q, Wang J, He X, Chen Y, Yan H, Liu J, Wang A, Wang W, Liu Q. Repurposing of clinical-stage FLT3 inhibitor HYML-122 as a potent RIPK2 inhibitor for the treatment of inflammatory bowel disease Int Immunopharmacol. 2025 Jun 26;159:114839. doi: 10.1016/j.intimp.2025.114839. Epub 2025 May 21.

Qi S, Cao J, Wu T, Shi C, Wang J, Wang B, Qi Z, Wu H, Wu Y, Wang A, Liu J, Wang W, Liu Q. Discovery of IHMT-15130 as a Highly Potent Irreversible BMX Inhibitor for the Treatment of Myocardial Hypertrophy and Remodeling. ACS Chem Biol. 2025 Jun 20;20(6):1181-1194. doi: 10.1021/acschembio.4c00875. Epub 2025 May 19.

Yan LJ, Qi S, Wu C, Jin R, Hu C, Wang AL, Wang BL, Yu HW, Wang L, Liu J, Qi ZP, Wang WC, Liu QS. Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation Acta Pharmacol Sin. 2025 Apr;46(4):1016-1029. doi: 10.1038/s41401-024-01434-1. Epub 2024 Dec 16.

Wang Y, Hu C, Yu H, Hu J, Zhou Z, Fu N, Huang X, Kong F, Wang W, Liu J. Insensitivity of oncogenic EGFR R776L mutation to EGFR inhibitors in lung cancer Lung Cancer. 2024 Mar;189:107495. doi: 10.1016/j.lungcan.2024.107495. Epub 2024 Jan 28.

承担项目

NTRK1激酶选择性增强CMV启动子转录活性的机制研究，国家自然科学基金/面上项目（2021）

干预调控CRL2FEM1 E3的小分子化合物及多肽开发，合肥大科学中心协同创新培育基金 (2021)

针对RAS和RAF突变实体瘤的pan-RAF抑制剂CHMFL-RAF-128的临床前个性化研究，中国科学院任务/战略性先导科技专项/前瞻战略科技（A）（2019）