代表性论文

Huang Guangyao, Hao Sensen, Fang Yue, Pei Jing, Wang Ying, Shao Jingyuan, Bao Lanxin, Li Zhenxing, Cao Wen, Zhao Mancun, Hou Liujie, Wang Hongzhi*. BioGate SERS Chip enables robust metabolite-oriented nanobiotechnological detection of breast cancer margins[J]. Journal of Nanobiotechnology, 2026. DOI: 10.1186/s12951-026-04468-1.

Cao Wen, Huang Guangyao*, Fang Yue, Shao Jingyuan, Hao Sensen, Wang Ying, Tan Tinfei, Li Zhenxing, Zhao Mancun, Hou Liujie, Wang Junping*, Wang Hongzhi*. PlasmoBridge: Stable hotspot engineering and targeted Surface-enhanced Raman spectroscopy (SERS) monitoring of methotrexate[J]. Biosensors and Bioelectronics, 2026, 292: 118081. DOI: 10.1016/j.bios.2025.118081.

Shao Jingyuan, Chen Huabao, Li Qiankun, Huang Xiang, Shu Jiong, Liu Lingling, Dou Shaobin*, Wang Hongzhi*. Multi-stage dual-domain progressive network with synergistic training for sparse-view CT reconstruction[J]. Neural Networks, 2026, 195: 108221. DOI: 10.1016/j.neunet.2025.108221.

Fang Yue, Huang Guangyao*, Hao Sensen, Chen Bin, Hao Jiqing, Wang Ying, Liu Nan, Li Zhenxing, Cao Wen, Zhao Mancun, Jiang Hanghan, Bao Lanxin, Wang Junping, Wang Hongzhi*. A programmable matrix-robust plasmonic MetaRing biosensor for rapid SERS-based chemotherapeutic response profiling[J]. Biosensors and Bioelectronics, 2026, 304: 118621. DOI: 10.1016/j.bios.2026.118621.

Zhang Xiaopeng, Qi Jian, Wang Jialiang, Wang Zhipeng, Wang Yongguang, Hu Zongtao, Xu Ao*, Hong Bo*, Wang Hongzhi*. Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed-Type Thyroid Cancer[J]. Advanced Science, 2026, 13(1): e07602. DOI: 10.1002/advs.202507602.

Huang Xiang, Jiao Li, Cheng Xu, Fang Yue, Qi Jian, Hu Zongtao, Hong Bo*, Nie Jinfu*, Wang Hongzhi*. A TP53-Pathway-Based Prognostic Signature for Radiotherapy and Functional Validation of TP53I3 in Non-Small-Cell Lung Cancer[J]. Cancers, 2026, 18(3): 457. DOI: 10.3390/cancers18030457.

Wang Nianfei, Chen Wei, Shen Shumin, Qi Jian, Wang Shanghu, Wang Rong, Li Ming, Chen Zixiang, Chen Jiangming*, Hong Bo*, Wang Hongzhi*. Nuclear prostaglandin E synthase 3 promotes hepatocellular carcinoma growth with immunosuppressive macrophage polarization via the SP1/TGF-beta axis[J]. Molecular Biomedicine, 2026, 7(1): 37. DOI: 10.1186/s43556-026-00431-6.

Fu Meng, Zhu Qizhi, Qi Jian, Zhang Xiaopeng, Wang Zhipeng, Wang Jialiang, Huang Xiang, Hu Zongtao, Wang Wei*, Hong Bo*, Wang Hongzhi*. Integrated methylome analysis identifies an epigenetically silenced tumor suppressor RASA4 in small cell lung cancer[J]. Communications Biology, 2025, 9(1): 161. DOI: 10.1038/s42003-025-09440-7.

Shu Jiong, Shao Jingyuan, Liu Lingling, Huang Xiang, Mao Yuxiang, Chen Huabao, Cui Xiangli, Li Bingbing, Jia Jie, Fei Zhenle, Hu Zongtao, Yang Xianjun, Chu Yannan, Wang Hongzhi*. A noninvasive realtime body position monitoring system for the entire course of tumor radiotherapy[J]. npj Digital Medicine, 2025, 8(1): 136. DOI: 10.1038/s41746-025-01537-x.

Gao Jianing, Fang Jinman, Zhu Qizhi, Li Guoshu, Bi Ziran, Hu Yue, Hong Bo, Zhang Yuanwei*, Guo Shipeng*, Wang Hongzhi*. ProjectSVR: mapping single-cell RNA-seq data to reference atlases by supported vector regression[J]. Briefings in Bioinformatics, 2025, 26(6): bbaf586. DOI: 10.1093/bib/bbaf586.

Fang Yue, Yue Yi, Hao Sensen, Zhang Ying, Liu Nan, Wang Shengling, Li Yan, Wang Hongzhi*. Serpin B9 is Highly Expressed in Lung Adenocarcinoma and is Associated with Progression-Free Survival[J]. Journal of Inflammation Research, 2024, 17: 8881-8890. DOI: 10.2147/JIR.S472199.

Qi Jian, Hong Bo, Wang Shujie, Wang Jingyun, Fang Jinman, Sun Ruifang*, Nie Jinfu*, Wang Hongzhi*. Plasma cell-free DNA methylome-based liquid biopsy for accurate gastric cancer detection[J]. Cancer Science, 2024, 115(10): 3426-3438. DOI: 10.1111/cas.16284.

Shu Jiong, Zhang Jianguang, Jee Kyungwook, Liu Lingling, Hu Man, Huo Wanli, Cui Xiangli*, Wang Hongzhi*, Lu Hsiao-ming*. Impact of iodinated oil in proton therapy on relative stopping power of liver post-cTACE[J]. Physics in Medicine & Biology, 2024, 69(9): 09NT03. DOI: 10.1088/1361-6560/ad388b.

专利

王盈; 王宏志; 黄光耀; 方乐; 郝森森; 一种表柔比星血药浓度的SERS基底及检测方法，ZL202511496655.7B

王宏志; 曹文; 黄光耀; 方乐; 郝森森; 甲氨蝶呤检测DNA纳米颗粒芯片及其制备方法和应用，ZL202511257275.8

王毅欣; 王宏志; 马涛; 林琳; 基于多模态MRI的影像组学的胶质瘤术后放疗预测方法，ZL202510912439.X

方金满; 王宏志; 王亚军; 陈涛; 张远伟; 左霄; 王薇; 邓天阳; 张雨欣; 魏丹丹; 张建锋; 王立荣; 王伟; 汤振; 张兵; 孙瑞霞; 蒋琼慧; 李志磊；预测结直肠癌新辅助化疗敏感性的微生物标志物组合及其应用，ZL202510861758.2

王宏志; 方乐; 黄光耀; 郝森森; 刘楠; 曹文; 蒋杭含; 一种紫杉醇耐药性SERS基底及检测方法，ZL202510453992.1

王盈; 王宏志; 黄光耀; 方乐; 郝森森; 一种表柔比星血药浓度的SERS基底及检测方法，ZL202511496655.7B

王宏志; 程旭; 张雨欣; 赵国平; 李雪玲; 基于临床数据和影像组学特征的食管瘘风险预测方法，ZL202411249157.8

王毅欣; 王宏志; 马涛; 林琳; 基于多模态MRI的影像组学的胶质瘤术后放疗预测方法，ZL202510912439.X

王宏志; 黄祥; 聂金福; 王姝洁;齐健; 一组用于预测非小细胞肺癌放疗预后的基因标签及应用，ZL202410846192.1

王宏志; 叶芳; 洪波; 聂金福; 方志友; 陈学冉; 一种非小细胞肺癌相关的InCRNA分子标记及其应用，ZL202310737370.2

承担项目

基于新型cfMeDIP-seq甲基化检测的肺结节良恶性无创分子诊断技术研发与临床应用，合肥市关键共性技术研发和重大科技成果工程化项目，2021YL007，2021.09-2023.08，项目负责人

基于柔性压力传感器的智能床垫系统研发及其在放疗中的应用，安徽省重点研究与开发计划，202004j07020052，2020.01-2022.12，项目负责人

多模态影像在恶性肿瘤质子精准治疗中的关键技术和临床应用，科技部国家重点研发计划，2018YFE0114100，2020.1–2022.12，子课题负责人

自主作业机器人智能发育验证平台关键技术，科技部国家重点研发计划，2017YFB1300204，2017.12-2020.11，子课题负责人

用于人体肺部重大疾病研究的磁共振成像仪器系统研制，基金委国家重大科研仪器设备研制专项，81227902，2013.1-2017.12，子课题负责人