简 介

蒋远，女，中国科学院合肥物质科学研究院研究员，博士生导师。

2016年于中国科学院动物研究所毕业获得理学博士学位，2016年至2020年先后在新加坡国立大学癌症研究所（Cancer Science Institute）和美国加州大学洛杉矶分校医学院Cedars-Sinai医学中心H. Phillip Koeffler课题组从事博士后研究，2020年12月回国加入中国科学院合肥物质科学院健康与医学技术研究所，先后任副研究员、项目研究员、研究员。重点围绕肿瘤患者的临床需求，开展表观遗传调控与肿瘤免疫的基础与转化研究。相关研究成果发表在Gastroenterology、Nature Communications、Cancer Research等期刊。入选中科院百人计划并获择优支持、安徽省重点引进人才。

承担科研项目情况

国家自然科学基金委青年和面上项目、中科院战略性科技先导专项C子课题、安徽省杰青项目、安徽省自然科学基金面上项目等。

社会任职

中国抗癌协会肿瘤病因专委会委员，合肥市女科技工作者协会会员，Cell Reports、EBioMedicine和J Exp Clin Canc Res等杂志审稿人。

研究方向

1. 增强子介导的表观遗传调控事件在肿瘤发生发展和临床治疗中的作用。

2. 可再生细胞体系构建与应用研究。

代表性论著

1.Kong S^#, Pan H^#, Zhang YW^#, Wang F, Chen J, Dong J, Yin C, Wu J, Zhou D, Peng J, Ma J, Zhou J, Ge D, Lu Y, Wei DD, Fang J, Han W, Shen C, Koeffler HP, Wang B^*, Jiang Y^*, Jiang YY^*. Targeting aldehyde dehydrogenase ALDH3A1 increases ferroptosis vulnerability in squamous cancer. Oncogene. 2025 Apr;44(15):1037-1050.

2.Jiang Y^#, Zheng YY^#, Zhang YY^#, Kong S^#, Dong J, Wang F, Ziman B, Gery S, Hao JJ, Zhou D, Zhou J, Ho AS, Sinha UK, Chen J, Zhang S, Yin C, Wei DD, Hazawa M, Pan H, Lu Z, Wei WQ, Wang MR, Koeffler HP, Lin DC^*, Jiang YY^*. Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer. Nat Commun. 2024 Mar 20;15(1):2484.

3.Rehman S^#, Kong S^#, Zhang J, Xia H, Chen R, Guo Z, Li Z, Ahmed R, Rehman A, Hossein Kazemian H, Jiang YY, Xu S, Jiang Y^*, Ma K^*, Wang J^*. Hydrophilic Metal–Organic Frameworks Regulated by Biomineralized Protein for Enhanced Stability and Drug Delivery. Nano Letters. 2024 Dec 11;24(49):15652-15661.

4.Jiang Y^#, Zhao H^#, Kong S, Zhou D, Dong J, Cheng Y, Zhang S, Wang F, Kalra A, Yang N, Wei DD, Chen J, Zhang YW, Lin DC^*, Meltzer S^*, Jiang YY^*. Establishing mouse and human oral esophageal organoids to investigate the tumor immune response. Dis Model Mech. 2024 Jan 1;17(1):dmm050319.

5.Wei DD^#, Fang JM, Wang HZ, Chen J, Kong S, Jiang YY^*, Jiang Y^*. Perioperative immunotherapy for esophageal squamous cell carcinoma. Front. Immunol. 2024 Feb 19:15:1330785.

6.Jiang YY^#, Jiang Y^#,*, Li CQ^#, Zhang Y^#, Dakle P^#, Kaur H, Deng JW, Lin RYT, Han L, Xie JJ, Yan YW, Doan N, Zheng YY, Mayakonda A, Hazawa M, Xu L, Li YY, Aswad L, Jeitany M, Kanojia D, Guan XY, Said JW, Yang W, Fullwood MJ^*, Lin DC^*, Koeffler HP. TP63, SOX2 and KLF5 Establish Core Regulatory Circuitry and Construct Cancer Specific Epigenome in Esophageal Squamous Cell Carcinoma Cell lines. Gastroenterology. 2020 Oct; 159 (4): 1311–1327.

7.Jiang Y^#, Jiang YY^#,*, Xie JJ^#, Mayakonda A^#, Chen L, Xiao JF, Li CQ, Huang ML, Ding LW, Sun QY, Xu L, Kanojia D, Jeitany M, Deng JW, Liao LD, Soukiasian HJ, Berman BP, Hao JJ, Xu LY, Li EM, Wang MR, Bi XG, Lin DC^*, Koeffler HP. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nat Commun. 2018 Sep 6; 9 (1): 3619.

8.Jiang Y^#, Jiang YY^#,*, Mayakonda A, Huang ML, Ding LW, Lin H, Yu FG, Lu YN, Loh TS, Chow M, Savage S, Tyner JW, Lin DC^*, Koeffler HP^*. Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma. Cancer Res. 2017 Dec 1; 77 (23): 6614-6626.

9.Xie JJ^#,*, Jiang YY^#, Jiang Y^#, Li CQ, Lim MC, An A, Mayakonda A, Ding LW, Long L, Sun C, Lin LH, Chen L, Wu JY, Wu ZY, Cao Q, Fang WK, Yang W, Meltzer SJ, Yang H, Fullwood M, Xu LY^*, Li EM^*, Lin DC^*, Koeffler HP. Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma. Gastroenterology. 2018 Jun; 154 (8): 2137-2151.

10.Jiang Y^#, Jiang YY^*, Lin DC^*. Super-enhancer-mediated core regulatory circuitry in human cancer. Comput Struct Biotechnol J. 2021 May 5; 19: 2790-2795.

11.Li LY^#,*, Yang Q^#, Jiang YY^#, Yang W^#, Jiang Y^#, Li X, Hazawa M, Zhou B, Huang GW, Gery S, Ding LW, Ho AS, Zumsteg ZS, Wang MR, Freedland SJ, Xu LY^*, Li EM^*, Koeffler HP, Lin DC^*. Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer. Nat Commun. 2021 Jul 16; 12 (1): 4362.

12.Hazawa M^#,*, Ikliptikawati DK^#, Iwashima Y^#, Lin DC^#, Jiang Y^#, Qiu Y, Makiyama K, Matsumoto K, Kobayashi A, Nishide G, Keesiang L, Yoshino H, Minamoto T, Suzuki T, Kobayashi I, Meguro-Horike M, Jiang YY, Nishiuchi T, Konno H, Koeffler HP, Hosomichi K, Tajima A, Horike S, Wong RW^*. Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells. Cell Chem Biol. 2024 Apr 18;31(4):792-804.e7.

13.Jiang Y^#, Yan L^#, Xia LK, Lv XY, Zhu WL, Ding DW, Du MX, Zhang D, Wang HM^*, Hu BY^*. Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells. J Biol Chem. 2018 Dec 14; 293 (50): 19317-19329.

14.Jiang Y^#, Du MX^#, Wu MH, Zhu YB, Zhao X, Cao X, Li X, Long P, Li W^*, Hu BY^*. Phosphatidic acid improves reprogramming to pluripotency by reducing apoptosis. Stem Cells Dev. 2016 Jan 1; 25 (1): 43-54.

15.Jiang Y, Zhang MJ and Hu BY. Specification of functional neurons and glia from human pluripotent stem cells. Protein Cell. 2012, 3 (11): 818-25.

专利

1. 蒋远；杜明霞；胡宝洋。一种提高体细胞重编程效率的培养基及方法，发明专利ZL 2015 1 0528329.X。

2. 蒋远；周丹；蒋焱熠；孔帅。类器官预包埋模具、类器官预包埋装置及预包埋方法，发明专利CN202310246618.5。

3. 蒋焱熠；蒋远；周丹；王飞；董锦绣；张硕。肿瘤类器官与肿瘤特异性细胞毒性T细胞共培养模型及其制备方法，发明专利CN202311383314.X。

4. 蒋焱熠；蒋远；董锦绣；孔帅；周丹；尹纯同。Trp63基因的表达抑制剂在制备改善鳞癌免疫治疗疗效的药物中的应用，CN202311497087.3。

5. 蒋远；周丹；蒋焱熠。增强子的转录活性的鉴定方法及其在食管癌检测和治疗中的应用，CN202410278788.6。

6. 蒋焱熠；张硕；蒋远。检测 CD74 表达量的试剂在制备鳞癌免疫治疗疗效预测产品中的应用，CN202410464223.7。

联系方式

地址：安徽省合肥市蜀山湖路350号科学岛健康与医学技术研究所，邮编：230031

电子邮箱：yuanj@cmpt.ac.cn