简  介

蒋焱熠，男，中国科学院合肥物质院健康所副所长、研究员、中国科学技术大学博士生导师。2014年7月于中国医学科学院/北京协和医学院获理学博士学位，师从王明荣教授；2014年9月至2020年10月分别在新加坡国立大学（NUS）癌症研究所和加州大学洛杉矶分校（UCLA）医学院Cedars-Sinai 医学中心 H. Phillip Koeffler 教授课题组从事博士后研究；2021年加入中科院合肥物质科学研究院健康与医学技术研究所转化医学研究中心，创立癌变机理与精准诊疗课题组任课题组长，继续从事肿瘤个体化精准诊疗研究。

绘制和解析了食管癌的表观遗传修饰图谱，揭示了食管癌特异性核心转录调控网络，并发现表观遗传抑制剂的联合使用在抗肿瘤生长中的重要潜力。已发表 SCI 论文60余篇，总引用超3000次，包括消化道疾病知名期刊4篇，Gut（2篇）和 Gastroenterology（2篇）； Nature 系列期刊5篇，Nature Genetics 和 Nature Communications（4篇）等。入选中科院百人计划并获择优支持，主持国家自然科学基金、安徽省杰青和DeGregorio Foundation等科研项目。担任Nature Cell Biology、Nature Communications、Cell Reports Medicine、Advanced Science和Cell Reports等杂志审稿人。 

研究领域

 针对严重影响人民生命健康的重大疾病，如恶性肿瘤，（1）运用单细胞测序技术和多组学等技术，阐释影响肿瘤免疫治疗效果的重要因素和相关微环境事件，解析不同患者免疫疗效差异性的细胞和分子学基础；（2）开发不同生理病理状态下的类器官模型及共培养体系，建立癌症治疗疗效评估平台，挖掘合理的临床诊疗新标志物和新策略。

代表性论著

1. Shuai Kong^#, Huaguang Pan^#, Yuan-Wei Zhang^#, Fei Wang, Jian Chen, Jinxiu Dong, Chuntong Yin, Jiaqi Wu, Dan Zhou, Jingyi Peng, Junboya Ma, Jianian Zhou, Dianlong Ge, Yan Lu, Dan-Dan Wei, Jinman Fang, Wei Han, Chengyin Shen, H. Phillip Koeffler, Boshi Wang^*, Yuan Jiang^*, Yan-Yi Jiang^*. Targeting super-enhancer associated oncogene-ALDH3A1 enhances ferroptosis sensitivity in squamous cancer. Oncogene. 2025 Apr;44(15):1037-1050.
2. Yuan Jiang^#, Yue-Yuan Zheng^#, Yuan-Wei Zhang^#, Shuai Kong^#, Jinxiu Dong; Fei Wang, Benjamin Ziman, Sigal Gery, Jia-Jie Hao, Dan Zhou, Jianian Zhou, Allen S. Ho, Uttam K. Sinha, Jian Chen, Shuo Zhang, Chuntong Yin, Dan-Dan Wei, Masaharu Hazawa, Huaguang Pan, Zhihao Lu, Wen-Qiang Wei, Ming-Rong Wang, H. Phillip Koeffler, De-Chen Lin^*, Yan-Yi Jiang^*. Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer. Nature Communications. 2024 Mar 20;15(1):2484.
3. Yuan Jiang^#, Hua Zhao^#, Shuai Kong, Dan Zhou, Jinxiu Dong, Yulan Cheng, Shuo Zhang, FeiWang, Andrew Kalra, Nina Yang, Dan-Dan Wei, Jian Chen, Yuan-Wei Zhang, De-Chen Lin^*, Stephen J.Meltzer^*, Yan-Yi Jiang^*. Establishing mouse and human oral esophageal organoids to investigate the tumor immune response. Disease Models & Mechanisms. 2024 Jan 1;17(1).
4. Tiantian Jing^#, Dianhui Wei, Xiaoli Xu, Chengsi Wu, Lili Yuan, Yiwen Huang, Yizhen Liu, Yan-Yi Jiang^*, Boshi Wang^*. Transposable elements-mediated recruitment of KDM1A epigenetically silences HNF4A expression to promote hepatocellular carcinoma. Nature Communications. 2024 Jul 4;15(1):5631.
5. Xie H^#,*, Yan-Yi Jiang^#, Xiang Y^#, Baoming Wu^#, Zhao J, Huang R, Wang M, Wang Y, Liu J, Wu D, Tian D^*, Bian E^*. Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia. Neuro Oncol. 2024 Aug 5;26(8):1438-1452.
6. Dan D. Wei^#, Jin M. Fang, Huan Z. Wang, Jian Chen, Shuai Kong, Yan-Yi Jiang^*, Yuan Jiang^*. Perioperative immunotherapy for ESCC, Frontiers in Immunology. 2024 Feb 19:15:133078.     
7. MengTing Wang^#, QingYang Chen^#, ShuJie Wang^#, Han Xie, Jun Liu, RuiXiang Huang, YuFei Xiang, Yan-Yi Jiang^*, DaSheng Tian*, ErBao Bian*. J Exp Clin Cancer Res. 2023 42:183.
8. Jiang Y^#, Yan-Yi Jiang^*, Lin DC^*. Super-enhancer-mediated core regulatory circuitry in human cancer. Comput Struct Biotechnol J. 2021 May 5;19:2790-2795.
9. Li LY^#,*, Yang Q^#, Yan-Yi Jiang^#, Yang W, Jiang Y, Li X, Hazawa M, Zhou B, Huang GW, Gery S, Ding LW, Ho AS, Zumsteg ZS, Wang MR, Freedland SJ, Xu LY^*, Li EM^*, Koeffler HP, Lin DC^*. Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer. Nature Communications. 2021 Jul 16; 12 (1): 4362.
10. Chen L^#, Huang M^#, Plummer J^#, Pan J^#, Yan-Yi Jiang^#, Yang Q, Silva TC, Gull N, Chen S, Ding LW, An O, Yang H, Cheng Y, Said JW, Doan N, Dinjens WN, Waters KM, Tuli R, Gayther SA, Klempner SJ, Berman BP^*, Meltzer SJ^*, Lin DC^*, Koeffler HP^*. Master transcription factors form inter-connected circuitry and orchestrate transcriptional network in EAC. Gut. 2020 Apr; 69 (4): 630-640.
11. Yan-Yi Jiang^#, Jiang Y^#*, Li CQ^#, Zhang Y^#, Dakle P^#, Kaur H, Deng JW, Lin RYT, Han L, Xie JJ, Yan YW, Doan N, Zheng YY, Mayakonda A, Hazawa M, Xu L, Li YY, Aswad L, Jeitany M, Kanojia D, Guan XY, Said JW, Yang W, Fullwood MJ^*, Lin DC^*, Koeffler HP. TP63, SOX2 and KLF5 Establish Core Regulatory Circuitry and Construct Cancer Specific Epigenome in ESCC. Gastroenterology. 2020 Oct;159(4):1311-1327.e19.
12. Jiang Y^#, Yan-Yi Jiang^#*, Xie JJ^#, Mayakonda A^#, Chen L, Xiao JF, Li CQ, Huang ML, Ding LW, Sun QY, Xu L, Kanojia D, Jeitany M, Deng JW, Liao LD, Soukiasian HJ, Berman BP, Hao JJ, Xu LY, Li EM, Wang MR, Bi XG, Lin DC^*, Koeffler HP. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nature Communications. 2018 Sep 6; 9 (1): 3619.
13. Xie JJ^#, Yan-Yi Jiang^#, Jiang Y^#, Li CQ, Lim MC, An A, Mayakonda A, Ding LW, Long L, Sun C, Lin LH, Chen L, Wu JY, Wu ZY, Cao Q, Fang WK, Yang W, Meltzer SJ, Yang H, Fullwood M, Xu LY^*, Li EM^*, Lin DC^*, Koeffler HP. SE-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in SCC. Gastroenterology. 2018 Jun; 154 (8): 2137-2151.
14. Yan-Yi Jiang ^#*, Lin DC^#*, Mayakonda A^#, Hazawa M, Ding LW, Chien WW, Xu L, Chen Y, Xiao JF, Senapedis W, Baloglu E, Kanojia E, Shang L, Xu X, Yang H, Tyner JW^*, Wang MR^*, Koeffler HP. Targeting Super-Enhancer associated oncogenes in esophageal squamous cell carcinoma. Gut. 2017 Aug; 66 (8): 1358-1368.
15. Jiang Y^#, Yan-Yi Jiang^#*, Mayakonda A, Huang ML, Ding LW, Lin H, Yu FG, Lu YN, Loh TS, Chow M, Savage S, Tyner JW, Lin DC^*, Koeffler HP^*. Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma. Cancer Res. 2017 Dec 1; 77 (23): 6614-6626.
16. Hao JJ^#, Lin DC^#, Dinh HQ^#, Mayakonda A^#, Yan-Yi Jiang^#, Chang C, Jiang Y, Lu CC, Shi ZZ, Xu X, Zhang Y, Cai Y, Wang JW, Zhan QM, Wei WQ, Berman BP^*, Wang MR^*, Koeffler HP^*. Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nat Genet. 2016 Dec; 48 (12): 1500-1507.
17. Yan-Yi Jiang^#, Shang L, Shi ZZ, Zhang TT, Ma S, Zhang Y, Hao JJ, Shi C, Shi F, Xu X, Cai Y, Zhan QM, Wang MR^*. Microtubule-associated protein 4 (MAP4) is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma. Oncogene. 2016 Sep15; 35 (37): 4846-56.

联系方式

地址：安徽省合肥市蜀山湖路350号科学岛健康与医学技术研究所，邮编：230031

电子邮箱：yanyij@cmpt.ac.cn