一、团队简介

    癌变机理与精准诊疗团队成立于2021年，由蒋焱熠研究员担任团队负责人。团队紧密围绕健康中国战略，针对亟需提升肿瘤免疫治疗疗效的临床需求，重点开展我国高发消化道肿瘤的精准免疫诊疗研究。已发表研究论文70余篇，刊登在Gastroenterology、Nature Communications、Cancer Research等国际知名期刊，已开展IIT临床试验2项，初步形成了从基础研究成果向临床应用转化的研究闭环。

二、研究方向

1. 肿瘤精准免疫诊疗策略开发

运用多组学数据，阐释影响肿瘤免疫治疗效果的重要因素和相关微环境事件，解析不同患者免疫疗效差异性的细胞和分子学基础，探索提升临床免疫治疗疗效新策略，开展临床验证试验。

2. 肿瘤细胞命运决定

依托临床队列数据，融合人工智能模型解析肿瘤细胞动态演化规律，挖掘调控细胞命运关键分子，探索肿瘤进展转移机制，为精准诊疗新靶点发掘提供理论支撑。

3. 基因编辑与类器官技术的医学应用研究

开发不同生理病理状态下的类器官模型及共培养体系，建立肿瘤治疗疗效评估平台，挖掘合理的临床诊疗新标志物和新策略。

三、研究团队

 蒋焱熠 研究员                                      蒋远 研究员                                    马凯 副研究员

    癌变机理与精准诊疗团队由蒋焱熠、蒋远、马凯担任学科带头人。现有成员27人，汇聚了基础科研、临床医师、数据分析等多领域人才，搭建了多梯度科研队伍。其中，研究员2名、副研究员1名、博士后11名、博士和硕士研究生若干名；中国科学院引才计划入选者3人且已有2人获得择优支持，安徽省杰出青年项目获得者2人，国资博士后C类1人，承担国家基金委项目9项、中国科学院先导子课题1项等。

四、研究成果

1.  Shuai Kong#, Huaguang Pan#, Yuan-Wei Zhang#, Fei Wang, Jian Chen, Jinxiu Dong, Chuntong Yin, Jiaqi Wu, Dan Zhou, Jingyi Peng, Junboya Ma, Jianian Zhou, Dianlong Ge, Yan Lu, Dan-Dan Wei, Jinman Fang, Wei Han, Chengyin Shen, H. Phillip Koeffler, Boshi Wang*, Yuan Jiang*, Yan-Yi Jiang*. Targeting super-enhancer associated oncogene-ALDH3A1 enhances ferroptosis sensitivity in squamous cancer. Oncogene. 2025 Apr;44(15):1037-1050.

2.  Yuan Jiang^#, Yueyuan Zheng^#, Yuan-Wei Zhang^#, Shuai Kong^#, Jinxiu Dong; Fei Wang, Benjamin Ziman, Sigal Gery, Jia-Jie Hao, Dan Zhou, Jianian Zhou, Allen S. Ho, Uttam K. Sinha, Jian Chen, Shuo Zhang, Chuntong Yin, Dan-Dan Wei, Masaharu Hazawa, Huaguang Pan, Zhihao Lu, Wen-Qiang Wei, Ming-Rong Wang, H. Phillip Koeffler, De-Chen Lin^*, Yan-Yi Jiang^*. Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer. Nat Commun. 2024 Mar 20;15(1):2484.

3.  Kai Ma^#, Kaili Yin^#, Jiong Li, Li Ma, Qun Zhou, Xiyuan Lu, Bo Li, Juxue Li, Gang Wei, Guo Zhang^*. The Hypothalamic Epigenetic Landscape in Dietary Obesity. Adv Sci (Weinh). 2024 Mar;11(9): e2306379.

4.  Yuan Jiang^#, Hua Zhao^#, Shuai Kong, Dan Zhou, Jinxiu Dong, Yulan Cheng, Shuo Zhang, FeiWang, Andrew Kalra, Nina Yang, Dan-Dan Wei, Jian Chen, Yuan-Wei Zhang, De-Chen Lin^*, Stephen J.Meltzer^*, Yan-Yi Jiang^*. Establishing mouse and human oral esophageal organoids to investigate the tumor immune response. Dis Model Mech. 2024 Jan 1;17(1).

5.  Tiantian Jing^#, Dianhui Wei, Xiaoli Xu, Chengsi Wu, Lili Yuan, Yiwen Huang, Yizhen Liu, Yan-Yi Jiang^*, Boshi Wang^*. Transposable elements-mediated recruitment of KDM1A epigenetically silences HNF4A expression to promote hepatocellular carcinoma. Nat Commun. 2024 Jul 4;15(1):5631.

6.  Han Xie^#,*, Yan-Yi Jiang^#, Yufei Xiang ^#, Baoming Wu^#,  Jiajia Zhao, Ruixiang Huang, Mengting Wang, Yunlong Wang, Jun Liu, Dejun Wu, Dasheng Tian ^*, Erbao Bian ^*. Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia. Neuro Oncol. 2024 Aug 5;26(8):1438-1452.

7.  Dan-Dan Wei^#, Jinman Fang, Huanzhong Wang, Jian Chen, Shuai Kong, Yan-Yi Jiang^*, Yuan Jiang^*. Perioperative immunotherapy for ESCC. Front Immunol. 2024 Feb 19:15:133078.    

8.  MengTing Wang^#, QingYang Chen^#, ShuJie Wang^#, Han Xie, Jun Liu, RuiXiang Huang, YuFei Xiang, Yan-Yi Jiang^*, DaSheng Tian*, ErBao Bian*. J Exp Clin Cancer Res. 2023 42:183.

9.  Kai Ma, Man Luo, Guanglei Xie, Xi Wang, Qilin Li, Lei Gao, Hongtao Yu, Xiaochun Yu^*. Ribosomal RNA regulates chromosome clustering during mitosis. Cell Discov. 2022, 8(1).

10. Yuan Jiang ^#, Yan-Yi Jiang^*, De-Chen Lin ^*. Super-enhancer-mediated core regulatory circuitry in human cancer. Comput Struct Biotechnol J. 2021 May 5;19:2790-2795.

11. Li-Yan Li ^#,*, Qian Yang ^#, Yan-Yi Jiang^#, Wei Yang, Yuan Jiang, Xiang Li, Masaharu Hazawa, Bo Zhou, Guo-Wei Huang, Xiu-E Xu, Sigal Gery, Ling-Wen Ding, Allen S. Ho, Zachary S. Zumsteg, Ming-Rong Wang, Melissa J. Fullwood, Stephen J. Freedland, Stephen J. Meltzer, Li-Yan Xu ^*, En-Min Li ^*, H. Phillip Koeffler, De-Chen Lin ^*. Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer. Nat Commun. 2021 Jul 16; 12 (1): 4362.

12. Li Chen ^#, Moli Huang ^#, Jasmine Plummer ^#, Jian Pan ^#, Yan-Yi Jiang^#, Qian Yang, Tiago Chedraoui Silva, Nicole Gull, Stephanie Chen, Ling-Wen Ding, Omer An, Henry Yang, Yulan Cheng, Jonathan W Said, Ngan Doan, Winand NM Dinjens, Kevin M Waters, Richard Tuli, Simon A Gayther, Samuel J Klempner, Benjamin P Berman^*, Stephen J Meltzer ^*, De-Chen Lin ^*, H. Phillip Koeffler ^*. Master transcription factors form inter-connected circuitry and orchestrate transcriptional network in EAC. Gut. 2020 Apr; 69 (4): 630-640.

13. Yan-Yi Jiang^#, Yuan Jiang ^#*, Chun-Quan Li ^#, Ying Zhang ^#, Pushkar Dakle ^#, Harvinder Kaur, Jian-Wen Deng, Ruby Yu-Tong Lin, Lin Han, Jian-Jun Xie, Yiwu Yan, Ngan Doan, Yueyuan Zheng, Anand Mayakonda, Masaharu Hazawa, Liang Xu, YanYu Li, Luay Aswad, Maya Jeitany, Deepika Kanojia, Xin-Yuan Guan, Jonathan W. Said, Wei Yang, Melissa J. Fullwood^*, De-Chen Lin ^*, H. Phillip Koeffler. TP63, SOX2 and KLF5 Establish Core Regulatory Circuitry and Construct Cancer Specific Epigenome in ESCC. Gastroenterology. 2020 Oct;159(4):1311-1327.e19.

14. Yuan Jiang ^#, Yan-Yi Jiang^#*, Jian-Jun Xie^#, Anand Mayakonda^#, Masaharu Hazawa, Li Chen, Jin-Fen Xiao, Chun-Quan Li, Mo-Li Huang, Ling-Wen Ding, Qiao-Yang Sun, Liang Xu, Deepika Kanojia, Maya Jeitany, Jian-Wen Deng, Lian-Di Liao, Harmik J. Soukiasian, Benjamin P. Berman, Jia-Jie Hao, Li-Yan Xu, En-Min Li, Ming-Rong Wang, Xin-Gang Bi, De-Chen Lin^*, H. Phillip Koeffler. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nat Commun. 2018 Sep 6; 9 (1): 3619.

15. Yan-Yi Jiang ^#*, De-Chen Lin^#*, Anand Mayakonda^#, Masaharu Hazawa, Ling-Wen Ding, Wen-Wen Chien, Liang Xu, Ye Chen, Jin-Fen Xiao, William Senapedis, Erkan Baloglu, Deepika Kanojia, Shang Li, Xin Xu, Henry Yang, Jeffrey W Tyner^*, Ming-Rong Wang^*, H. Phillip Koeffler. Targeting Super-Enhancer associated oncogenes in esophageal squamous cell carcinoma. Gut. 2017 Aug; 66 (8): 1358-1368.

16. Yuan Jiang ^#, Yan-Yi Jiang^#*, Anand Mayakonda, Mo-Li Huang, Ling-Wen Ding, Lin Han, Fenggang Yu, Yannan Lu, Thomas Kwok Seng Loh, Marilynn Chow, Samantha Savage, Jeffrey W Tyner, De-Chen Lin^*, H. Phillip Koeffler^*. Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma. Cancer Res. 2017 Dec 1; 77 (23): 6614-6626.

17. Jia-Jie Hao^#, De-Chen Lin^#, Huy Q Dinh^#, Anand Mayakonda^#, Yan-Yi Jiang^#, Chen Chang, Ye Jiang, Chen-Chen Lu, Zhi-Zhou Shi, Xin Xu, Yu Zhang, Yan Cai, Jin-Wu Wang, Qi-Min Zhan, Wen-Qiang Wei, Benjamin P Berman^*, Ming-Rong Wang^*, H. Phillip Koeffler^*. Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nat Genet. 2016 Dec; 48 (12): 1500-1507.

18. Yan-Yi Jiang^#, Li Shang, Zhi-Zhou Shi, Tong-Tong Zhang, Sai Ma, Yu Zhang, Jia-Jie Hao, Chao Shi, Feng Shi, Xin Xu, Yan Cai, Qi-Min Zhan, Ming-Rong Wang^*. Microtubule-associated protein 4 (MAP4) is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma. Oncogene. 2016 Sep15; 35 (37): 4846-56.

五、联系与合作

如果您对我们的研究团队感兴趣或有合作意向，欢迎随时与我们联系：

蒋焱熠：yanyij@cmpt.ac.cn

蒋  远：yuanj@cmpt.ac.cn

马  凯：kma@cmpt.ac.cn